This study aims to design a strategic model of e-business based on the outcomes of effectiveness in line with value creation. This study is descriptive-analytical in terms of its fundamental objective, and based on a qualitative approach to data-based theorizing in terms of its method. The tools used in this study were interviews and a statistical sample of 15 academic experts and e-business managers. The sampling method selected in this study was theoretical, which continued from in-depth interviews with experts until theoretical saturation was reached. In the analysis process, open, axial, and selective coding was used, and the content of related reports and interviews was analyzed using MAXQDA software, and 81 open codes (concepts) and 16 subcategories were obtained. The results of data analysis showed that causal conditions, 3 subcategories; planning and evaluation, market needs assessment, and customer online shopping experience, contextual conditions, 3 subcategories; Technical requirements, electronic maturity and e-commerce infrastructure, intervening conditions, 3 subcategories; specific characteristics of each business, government policies and facilitators, pivotal conditions, 3 subcategories; characteristics of distribution of goods and services, characteristics of exchange of goods and services, and characteristics of communication between buyer and seller, strategies, 2 subcategories; economic strategies of business and marketing and sales strategy, and the main category of consequences, 2 subcategories; effectiveness consequences for business and effectiveness consequences for customers.